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Firstly, observations in aged mice (2024-months-old) reveal morphological changes in astrocytes and alterations in territorial domain that may result in reduced contacts between adjacent astrocytes, disconnecting them from the greater pan-glial network which is essential for many homeostatic functions (e.g., K + spatial buffering, metabolic and cholesterol supply to oligodendrocytes

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thus, complete integration of clinical, histopathologic, and biochemical information is necessary for accurate diagnosis

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