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However, survival after liver transplantation is worse among patients with Type 1 HH compared to patients undergoing liver transplantation for other indications.37 Most of the post-transplant deaths are due to cardiac complications or infection.38 Though iron chelators are the treatment of choice in iron overload associated with hemolytic anemias, they are generally not used in HH because of the increased risk of toxicity and need for parenteral administration

L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH) [2]

The mutations generated by Cas9 at the target exons were obtained by preparing genomic DNA from the selected clones and amplifying the exons with the primers: Fwd (hA5-ck1): 5-TCTTGTATCTGTACCTCTGA-3

The price for Glutathione injections starts at approximately $154 for the first month, which is a competitive rate for this type of treatment

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