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Animal studies showed retatrutide producing lower expression levels of inflammatory and fibrotic mediators compared to tirzepatide, suggesting the triple mechanism may offer benefits beyond additional weight loss

Supplementary Table 3

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miRNAs involved in the regulation of adipogenic transcription factors were evaluated by RT-qPCR, and highly potent steric-blocking oligonucleotides (miRNA inhibitors) were used to modulate miRNAs expression

This stage is linked with tissue repair, hormone timing, and parts of immune defense