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Klinika ispitivanja i zahtjev za davanje odobrenja pokree sponzor/podnositelj zahtjeva, dok nadlena tijela (u okviru svojih ovlasti) provode znanstvenu i strunu ocjenu dostavljene dokumentacije te na temelju te ocjene donose odluku

The theory of the origin of sleep which has gained the widest credence is the one that attributes it to anemia of the brain The idea behind this supposition has been that, as the day draws to an end, the circulatory mechanism becomes fatigued, the vasomotor center exhausted, the tone of the blood vessels deficient, and the energy of the heart diminished, and thus is the circulation to the cerebral arteries lessened. NATURE, May 5th, 1898

Post-Exertional Malaise (PEM): While not a cure for PEM, by protecting mitochondria from the massive oxidative stress generated during exertion, melatonin may help raise the threshold for crashes and shorten recovery times

The signaling through these neurons is increased by ghrelin and attenuated by leptin

Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial

Spermidine has also been shown to be associated with a delay is age-related cognitive decline