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Cell signaling: H2O2, a necessary evil for cell signaling

The liver has the major responsibility for detoxification, and GSH is the cornerstone of this process

Schmoll et al., 2003

DOPAL Neurotoxicity Amongst the several determinants of the degeneration of SNpc DA neurons, the possible endotoxicity associated to dopamine dyshomeostasis is an important factor to consider

13 C NMR (151 MHz, DMSO-d 6 ) 178.3 (PtO C (=O)CH 3 ), 173.2 (B-10), 163.9, 163.8 (d, B-9), 163.4, 163.4 (PtO C (=O) 2 ), 61.1, 60.8 (D-2), 53.4, 53.2 (d, B-4), 52.9, 52.9 (d, B-7), 50.7, 50.6 (d, B-5), 31.0, 30.9 (D-3), 24.7, 24.6 (d, B-6), 24.1, 24.0 (d, B-3), 23.5, 23.5 (D-4), 22.9 (PtOC(=O) C H 3 ), 21.1 (B-2), 13.6 (B-1)

Ascorbate is required for the maintenance of activity of Fe(II)/2-oxoglutarate-dependent dioxygenases via reduction of Fe(III)