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H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Granatiero et al., 2019) (Figure 7)

Importantly, under cellular and in vivo conditions, DSePA was shown to induce the mRNA and activity levels of seleno-GPxs [85]

doi: 10.1016/j.tox.2004.09.002

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In a first, but general reaction, methionine is converted into S-adenosyl-L-methionine (SAM) by SAM synthetase using ATP (Murr and Yang, 1975

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