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The ferroptosis inducer RSL3 can induce ferroptosis in synoviocytes and exacerbate synovial inflammation, leading to upregulation of transferrin receptor 1 (TFR1) and nuclear receptor coactivator 4 (NCOA4)

Cistena + Glutamina + Glicina A glutationa produzida a partir de nutrientes especficos: aminocidos que formam a sua estrutura (cistena, glutamina e glicina), vitaminas e minerais que participam das reaes complementares durante o seu processo de sntese (vitamina B2, magnsio e selnio)

The expression of the cystine/glutamate transporter is induced in the context of high oxidative stress and cell proliferation, ,, and its inhibition hinders glutathione synthesis leading to ferroptosis

10.1210/en.2008-2286 Endocrinology 118 PapaV.GliozzoB.ClarkG

Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors