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Philadelphia (PA): Lippincott Williams & Wilkins, 2002: 780 Gugler R, von Unruh GE

Front Immunol (2021) 12:694217
Epub 2013/03/14

In its neutral form, the imidazole side chain has an "ambidextrous" nature, since the nitrogen without a hydrogen is nucleophilic and can act as a hydrogen bond acceptor, while the nitrogen with the hydrogen bond is electrophilic and can act as a H-bond donor

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