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Butyrate, in particular, binds to receptors on astrocytes, suppresses neuroinflammation, enhances neurotrophic factor expression, and reduces seizure frequency in epileptic rats (Citraro et al., 2021)

A defect in folate metabolism involving the presence of the variant C677T, which leads to reduced MTHFR activity, is correlated with lowered blood folate levels [29]

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Metabolic profiling by Seahorse assay suggested that melatonin treated ILC2s exhibited decreased rates of basal respiration ( Figure 5P ), decreased spare respiratory capacity ( Figure 5Q ), and both reduced active rates of glycolysis ( Figure 5R ) as well as reduced glycolytic capacity ( Figure 5S )