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Given that osteoarthritis involves cartilage degradation and inflammation, BPC-157s potential anti-inflammatory and regenerative properties make it a compound of interest for studying OA, but definitive conclusions require much more research.

Disclosure of interest: Katrine Svrke: Nothing to disclose

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A global, phase 1/2, open-label, dose optimization study to evaluate the safety, pharmacodynamics, and pharmacokinetics of mRNA-3927 in participants with propionic acidemia

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The dose-response curve between 8 and 12 mg shows diminishing returns, meaning 10 mg captures most of the benefit while potentially reducing some of the dose-related side effects seen at 12 mg