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Description
Introduction Copper (Cu) is a ubiquitous trace element stored primarily in the liver, but also present in other organs, such as the brain, heart, kidney, and muscles (Osredkar and Sustar, in vivo regulation of copper levels in biological systems is under strict control through the actions of copper transporters and chaperones (Harris, Defects in the ATP7B gene encoding a copper transporting Cu-ATPase disrupt the homeostatic copper balance leading to Wilson disease (WD), that is characterized by reduced biliary Cu excretion, and impaired Cu incorporation into Cp (Cox and Moore, D-Penicillamine (PA) (Figure 1A), first identified as a product of penicillin hydrolysis, is the drug of choice to treat WD patients, is marketed as Cuprimine or Depen (Stephenson and Roberson, 2 ) groups forming a non-toxic ring complex (Figure 1B

DOI: 10.1053/meta.2002.35181 Sigue leyendo: Profundiza en la ciencia:

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In this context, taurine appears to attenuate As2O3 mediated toxicity (249), possibly by reducing the expression levels of phosphorylated JNK kinases, thereby ruling out the possibility that hepatic cells follow the apoptotic route after taurine treatment in As2O3-administered rats (248)
