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Moreover, the addition treatment of l-Carnitine eliminated the upregulation of IRE1 (a biomarker of ER stress), Beclin, and LC3BII (a biomarker of autophagy) in the RTCs treated with PFOS for 24 h (Fig

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

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So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets

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