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APH is a potent DNA polymerase inhibitor which has been shown to modulate mitochondrial DNA replication

Myristoylation at the N-terminus of the FSP1 protein, a lipid modification, facilitates the localization of FSP1 to the plasma membrane

Xenobiotics in particular need to hitchhike on protein transporters that have presumably evolved for natural substrates but that are capable of their uptake (142152)

What Needs to Be in Place Before a First-in-Human Trial Begins Before entering a First-in-Human trial, a drug candidate must be supported by a comprehensive package of scientific, non-clinical and quality evidence

doi: 10.1016/j.mehy.2021.110736

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