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Matsumoto K, Ohfuji S, Abe M, Komori A, Takahashi A, Fujii H, et al

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In TME, higher levels of milk fat globule-epidermal growth factor 8 (MFGE8) promote efferocytosis by stimulating macrophages to remove cisplatin-induced apoptotic cells, contributing to the lethal consequences of chemotherapeutic resistance (Ma et al., 2024)

For instance, primary microglial cells from aged (1824-months-old) rats treated with an inflammatory stimulus [i.e., transforming growth factor- (TGF-)] creates a microglial-deposited ECM that promotes the differentiation of OPCs into astrocytes, thereby preventing oligodendrocyte differentiation and myelination (Baror et al., 2019)

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