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Mitochondrial fusion proceeds through three distinct steps: transtethering of adjacent mitochondria, membrane docking to increase the contact surface area and reduce the intermembrane distance [98], and outer membrane fusion driven by GTP hydrolysisinduced conformational changes in mitofusins [99, 100]

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For individuals living with complex, chronic conditions like Long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and dysautonomia, the daily reality is often defined by a profound, unyielding lack of energy

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PMID 11278763

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