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It can increase serum insulin and reduce blood glucose levels in diabetic mice [184]
A coculture model of HCC with monocytes revealed that NRF2 activation in macrophages induces an M2-like phenotype, promoting VEGF elevation in cancer cells and subsequent EMT 122

Disordered lipid metabolism and the pathogenesis of insulin resistance
Supporting ER activity helps maintain healthier fat distribution, glucose handling, vascular flexibility, and metabolic resilience
Salvaggio, J

These enzymes determine the rate of mitochondrial oxygen utilization, ROS production, oxidative stress and ATP synthesis [15], [16], [39], [40], [41], [42], [43], [44]