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In this review, we systemically summarized the signal pathways driving melanoma pathogenesis, including the main mutated driver genes and signals, key transcriptional factors and downstream molecular biology, epigenetic modification, metabolic reprogramming, crucial metastasis-related signals, and tumor-promoting inflammatory pathways and pro-angiogenic factors

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Cells were then harvested, fixed with electron microscopy fixative, processed for sectioning, and stained prior to examination by transmission electron microscopy

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These include stabilizing -catenin, promoting its nuclear translocation, upregulating Frizzled and LRP5/6 expression, and inhibiting glycogen synthase kinase-3 (GSK-3) activity

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