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Furthermore, positive correlations were observed between CYP2E1 promoter methylation and both iNOS promoter methylation and urinary levels of SPMA

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However, restrictions such as a need to proceed efficiently at low protein loadings, solely in aqueous media, and to tolerate potential nonspecific binding to the multitude of possible Lewis-basic residues on protein surfaces, until recently, hindered the use of such reactions for site-specific protein modification