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In addition, traditionally it was thought that Met synthesis in plants requires transport of homocysteine from plastids to the cytoplasm, as the activity of the last enzyme of the biosynthetic pathway, MS, was found in this compartment only (Eichel et al., 1995)

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Additionally, while uncommon, some people might experience gastrointestinal side effects such as nausea, vomiting, or diarrhea, which could influence nutrient absorption and affect overall nutritional status if severe or persistent[272]

For example, a small number of subjects reported the following mild side effects in the course of a four-week glutathione study at the dose of 1g/day [13]: Flatulence Loose stools Flushing Weight gain In a more specialized study involving cystic fibrosis patients and much higher glutathione doses, some of the patients reported tightness in the torso, diarrhea, and fever-like symptoms [14]

Zhou M, Yu Y, Luo X, Wang J, Lan X, Liu P, Feng Y, Jian W (2021) Myocardial ischemia-reperfusion injury: therapeutics from a mitochondria-centric perspective

IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly