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then, a decrease of acetyl-CoA/CoA ratio can relieve the inhibition of PDH thus affecting glucose oxidation

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In consequence, acylcarnitines constitute an appreciable component of the tissue carnitine pool, and tissue and plasma concentrations of carnitine and acylcarnitines are together maintained within relatively narrow limits by a variety of mechanisms, which influence in turn innumerable aspects of carbohydrate and lipid metabolism, including the regulation of insulin secretion by pancreatic -cells and the determination of tissue insulin sensitivity

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Furthermore, TMAO-treated cardiomyocytes also revealed the build-up of glycogen and lipofuscin-like pigment, suggesting a mitochondrial dysfunction and lower ATP production that affects the contractile function of cardiomyocytes

Dazu zhlen [16, 19]: Lebensalter und Gesundheitszustand: Bei Kindern und Kleinkindern mit Mehrfachbehinderung kommt es ungleich hufiger zu einer Hypocarnitinmie als bei ansonsten gesunden lteren Personen mit Epilepsie