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the invention encompasses use of one or more cations of the invention to treat obesity or related chronic metabolic condition, including metabolic syndrome, pre-diabetes, type-2 diabetes, obesity-linked diseases (e.g., non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, CVDs, and the like)

These data suggest that the increased risk of anemia observed in patients with T2D treated with metformin cannot be explained by vitamin B12 deficiency

Symptoms of B12 deficiency include: Low energy and fatigue Digestive problems Depression and moodiness Insomnia Brain fog and memory loss Anemia Reduced immune system function Tingling or numbness in the extremities Swollen tongue Loss of vision or hearing Jaundice Kidney disease Pale skin Poor circulation in the extremities If you are over age 50 and are experiencing one or more of the above symptoms, boosting your intake of B12 cannot hurt, and it may provide a safe and inexpensive solution while preventing a wrong diagnosis

It is recommended to administer subcutaneously during the morning on an empty stomach

low correlations in daily B12 intakes have been linked to the large size of liver vitamin B12 stores (23mg) (Doets et al., 2013)