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Two preliminary randomized controlled trials indicated that supplementation with large doses of choline or betaine decreased plasma homocysteine levels in healthy men and CVD patients

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Results from a clinical trial of tea drinking habits and HDL in Chinese adults found that in people aged 60 years or older, serum HDL concentrations decreased more slowly in tea drinkers compared to non-tea drinkers, suggesting a significant association between tea consumption and HDL-C (81)

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Decreased Gut MicrobiomeDerived Indole3Propionic Acid Mediates the Exacerbation of Myocardial Ischemia/Reperfusion Injury Following Depression via the BrainGutHeart Axis. Redox Biology 81: 103580