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Prevalence estimates are even higher in certain subgroups of the population, such as minority racial/ethnic groups (especially non-Hispanic blacks and Mexican Americans) and people who are in the third trimester of pregnancy (170, 171)

doi: 10.1016/0891-5849(94)00159-h

Vitamin B12 is an essential cofactor in the folic acid metabolic cycle, both involved in the remethylation of Hcy to methionine (69)

PMID 10486279

doi: 10.3389/fbioe.2021.671321 Received 23 February 2021 Accepted 26 March 2021 Published 16 April 2021 Volume 9 - 2021 Edited by Yi-Rui Wu, Shantou University, China Reviewed by Xiaoyuan Wang, Jiangnan University, China

Isocitrate is then oxidized by cytosolic isocitrate dehydrogenase 1 to generate -ketoglutarate and NADPH, which are required for ROS detoxification