glutathione phase 1 detoxification Liver Metabolism: The 3 Phases of Glutathione-Mediated Conjugation of Anticancer Drugs:

Structural basis of pml-rara oncoprotein targeting by arsenic unravels a cysteine rheostat controlling pml body assembly and function

Figure 2 The biosorption mechanism involves the fast, reversible, and passive binding of EPS with heavy metals and is now available for loosely connected EPS (Ciani et al., 2024

Since glutamine is a substrate for glutathione synthesis, adequate mucosal cell glutamine may contribute towards improved healing after chemotherapy and radiation damage [84,85] as well as, interestingly, the simultaneous inhibition of glutathione levels in tumors, too [86,87,88,89]

87 Interestingly, a recent study found that Gpx4-dependent ferroptosis in neutrophils drives the pathogenesis of systemic lupus erythematosus (SLE), 88 suggesting that targeting ferroptosis-induced neutropenia may be a potential strategy for treating autoimmune diseases such as SLE

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doi: 10.1016/j.cmi.2020.04.007 70 WangRDingSLeiCYangDLuoH