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Pseudolaric acid b triggers ferroptosis in glioma cells via activation of nox4 and inhibition of xct

Lancet 364 , 18851895 (2004)

Glutathione levels are also found to be decreased in central nervous system disorders (such as Alzheimer disease and Parkinson disease), autism, cardiovascular system disorders (atherosclerosis), peripheral vascular disorders, diabetes and its complications, liver disease, acquired immunodeficiency syndrome/human immunodeficiency virus, and chronic obstructive pulmonary diseases

Catalase, glucose-6-phosphate dehydrogenase, and glutathione reductase are also part of the armamentarium we use to neutralize the effects of excessive oxidants

283285 Fig
