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Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with NAFLD

Biomarker Validation and Clinical Translation: The field must prioritize the validation of clinical biomarkers that accurately reflect ferroptosis activity (e.g., MDA, 4-HNE, extracellular ferritin)

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Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

These experiments confirmed that TFS demonstrated superior transdermal penetration compared to conventional liposomes

The delayed gastric emptying also enhances the incretin response, creating a complementary effect with GLP-1 based therapies