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Another study by Guo et al
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10.1111/bcp.13431 28 McCuneJ

Treatment response was evaluated by all-cause mortality as a primary outcome
suggested that HIF-1 is a crucial regulatory factor inducing breast cancer metastatic niche forming through activation of several elements of the lysyl oxidase (LOX) family, which catalyze collagen cross-linking in the lungs before BMDC recruitment (98)

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