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Clarification of benefit flexibility and coverage guidance for dual eligible special need plans and process to request to offer flexible supplemental benefits in contract year 2017

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Disc herniation can initiate further degenerative changes, because displaced nucleus and annulus tissue swells by 100300% within a few hours, losing much of its GAGs 23,24

Though the exact mechanism is not well understood, it is thought that estrogen deficiency leads to down regulation of the expression of transcellular calcium transport proteins plasma membrane calcium pump 1b (PMCA1b), transient receptor potential cation channel subfamily V member 5 (TRPV5) and calbindin-D 28K (CaBP28k) [95]