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After careful consideration of the public comments we received, we are finalizing our proposal to adopt the DC Function measure as an assessment-based outcome measure beginning with the CY 2025 HH QRP as proposed

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That maps to the first two titration tiers in standard protocols, which is where most researchers spend their first eight weeks

It modulates the nitric oxide (NO) system in a bidirectional manner, meaning it can counteract both NO-excess states (like those caused by L-arginine or NO donors) and NO-deficiency states (such as those induced by L-NAME)

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