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One of the first studies which investigated the effect of a natural compound on PFK-1 activity used resveratrol (1, 5, 15, 50, and 100 M), a polyphenol with already demonstrated antitumor properties

Lipid peroxides were unremarkable for most subjects

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism

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Mapping was performed using the reference genome BDGP6.46, INSDC Assembly GCA_000001215.4 (details provided in Supplementary Data 9)

Since scavenging of ROS essentially depends on endogenous and exogenous antioxidant defenses in living organisms, individuals with chronic or degenerative diseases are more susceptible to OS or OS-induced damage due to raised levels of oxidants and/or reduced levels of antioxidants
