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[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Watkins L.R., Hutchinson M.R., Johnston I.N., Maier S.F

Unlike anergy and exhaustion, T cell senescence is an irreversible process
The most common forms of cancer in which mutations in the IDH1 and IDH2 genes have been discovered are gliomas in the brain
They are crucial for processes such as metabolism, immune system support, and maintaining overall health

This principle of timing-dependent effects applies to many peptide dosing strategies and underscores the importance of understanding proper peptide dosing protocols

10.1038/35041687 81 FranceschiC.BonafM.ValensinS.OlivieriF.De LucaM.OttavianiE.et al (2000)
