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This GSH deficiency impairs both antioxidant responses and regulation of S-glutathionylation/deglutathionylation cycles (Dickerhof et al., 2017)

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Two key outcome variables, blood glucose levels and peripheral nerve fluorescence intensity, were selected based on the literature

Advise individuals that oral dosing should be used on an interim basis only and that the continuation injection dosage should be resumed at the earliest possible opportunity [see Dosage and Administration (2.4)]

The fourth step (for refractory/multi-joint OA) is integrate medical nutrition therapy (MNT) based on the previous steps, combined with high-dose -3 PUFAs (EPA + DHA 3 g/day) for enhanced anti-inflammation

doi: 10.1038/nature11351