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This study highlights the need to gain better insights into how best to intervene to prevent the development of heart failure in at-risk individuals. Other TMAO pathway studies by this research team have helped elucidate mechanisms in the development of cardiovascular and renal diseases and suggest a role for pharmacotherapeutic interventions

Antifibrotic role of inducible nitric oxide synthase

Lastly, despite PDE5i treatment has been proven a cost-effective therapeutic strategy, compared to no treatment [62], the relatively high cost of a chronic treatment with some reference/equivalent pharmaceutical formulations belonging to this category of drugs might still represent a limitation for patients with economic constraints, by contributing to treatment discontinuation

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