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To assess the self-cleavage activity of the NS1-5 polyprotein, driven by the NS2B-NS3 protease, we also generated a catalytically inactive mutant of NS1-5 (S835A), in which a critical serine residue in the NS3 proteases active site was substituted with alanine 8

Glutathione is a tripeptide made of three amino acids: cysteine, glutamic acid, and glycine

The presence of high concentrations of tyrosine in the locus coeruleus and the substantia nigra leads to increased melanin synthesis which confers on these brain regions a dark bluish coloration observable in brain sections

Global impairment of immediate-early genes expression in rett syndrome models and patients linked to myelination defects

Effects of N-acetylcysteine on brain glutamate levels and resting perfusion in schizophrenia

However, recent studies have shown that L-glutathione reduced can be absorbed intact, especially when using liposomal or sublingual delivery methods