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The shift in the cellular GSH-to-GSSG redox balance in favor of the oxidized species, GSSG, constitutes an important signal that can decide the fate of the abnormal apoptosis in the disease

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The NNT enzyme has a loss-of-function variant in C57BL/6J mice owing to a spontaneous mutation at the first exon and a multiple exon deletion (exon 711) in the NNT gene (99)

Randomised placebo-controlled trial of human recombinant insulin-like growth factor I plus intensive insulin therapy in adolescents with insulin-dependent diabetes mellitus