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The dysregulation of the opioid system in fibromyalgia is closely associated with a variety of neurobiological dysfunctions, including imbalances in major neurotransmitter systems, especially serotonin and noradrenaline [158]
Zaborek NA, Cheng A, Imbus JR, et al

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Animals also presented a reduction of tight junction protein ZO-1, suggesting other effects into BBB, and exhibited augment in lipid peroxidation in the brain [29]

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RepeatExplorer: a Galaxy-based web server for genome-wide characterization of eukaryotic repetitive elements from next-generation sequence reads
