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doi: 10.23736/S0026-4806.18.05681-1

Electron microscopic localization of lacZ expression in the proximal convoluted tubular cells of the kidney in transgenic mice carrying chimeric erythropoietin/lacZ gene constructs

Lorrain DS, Baccei CS et al (2003)

There was no significant difference in the mean wound epithelialization percentage between groups ( p = 0.290)

Alternatively, the level of ROS-generated in these cells may not be overcome by only overexpressing a single antioxidant enzyme, or, perhaps, the basal level of hydrogen peroxide is low such that its removal may promote apoptosis

Therefore, FOXO4 is a promising target for the development of senolytics