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In addition, other administration routes such as nasal, transdermal, vaginal, and rectal are investigated to potentially enhance therapeutic effects and maximize clinical efficacy of probiotics beyond oral delivery (218)

Introduction Schizophrenia (ScZ) is a severe mental illness associated with pronounced cognitive and sensory impairments that are thought to emerge from underlying impairments of neural circuits ( Recent evidence has implicated a disturbance in the balance between excitation and inhibition (E/I-balance), a mechanism that assures efficient information transfer in neural networks ( Evidence for E/I-balance abnormalities in ScZ comes from post-mortem studies that have examined alterations in GABAergic interneuron properties as well as N-methyl-D-aspartate receptor (NMDA-R) density

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This review included studies published in journals in the highest impact factor quartile in the General Medicine or Endocrinology and Metabolism or Nutrition and Dietetics areas

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Using network pharmacology and molecular docking, one study [559] identified 50 potential gene targets of esculetin against UC, including core genes such as AKT1, STAT1, CCND1, and PTGS2