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Human research demonstrated that methylcobalamin supplementation in patients with inadequate B12 levels improved CD4/CD8 ratio and NK cell activity, and augmented CD3-CD16+ cells, suggesting an important role in cellular immunity.[14] In other research, among homologues studied, methylcobalamin was shown to have the strongest antibody production enhancement on an in vitro system.*[15]

Mol Cell Biol 17:4406

Nakamura, M

doi: 10.1016/j.cca.2020.08.005 83 LandauR.HalperinR.SullivanP.ZiblyZ.LeibowitzA.GoldsteinD

The 1.0 mL volume may sting