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In the context of bone and cartilage regeneration, MenSCs cultured in osteogenic induction medium for 21 days presented marked morphological changes, along with significantly upregulated expression of key osteogenic markers such as alkaline phosphatase (ALP), secreted phosphoprotein 1 (SPP1), and bone gamma-carboxyglutamic acid-containing protein (BGLAP) (Skliut et al., 2021)

Remodeling enzymes

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The uncoupling process reduces mitochondrial membrane potential, ultimately reducing the production of ROS (28, 31), (Figure 1)

The subcutaneous route is used at much smaller doses than oral because a 100 mg injection would require two 50 mg vials and about 6 mL of liquid when each vial is mixed with 3.0 mL BAC water, which is too much for one subcutaneous site

All ChIP signals were normalized to the input (labeled as % of input on the vertical axis)