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This interaction is also referred to as incompatible interaction and is generally characterized by a vast transcriptional reprogramming after recognition of the pathogen/pest effector molecule(s) 18

Palmgren, M

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Based on these findings, and despite a convincing preclinical rationale, we suggest that factors contributing to failure of these clinical trials are likely to include toxicity, suboptimal treatment scheduling, and the lack of a predictive biomarker