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demonstrated that direct contact between LSECs and platelets triggers S1P secretion from platelets, which subsequently induces LSECs to produce IL-6 and VEGF, modulating DNA synthesis in hepatocytes

Nevertheless, pyridoxal phosphate and pyridoxamine phosphate are the active endogenous metabolites of vitamin B6 that are involved in various biochemical reactions, including the metabolism of macronutrients, synthesis of nucleic acids, hemoglobin, and neurotransmitters (52, 53)

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