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Metabolic reduction in the posterior cingulate cortex in very early Alzheimers disease

That shift of two to three points might not trigger a flag on a lab report, but your body notices it

Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ et al

Micron 42(3):275282
The effect on brain cells may be even greater due to the high lipid membrane content of this organ, and it is conceivable that a brain localized cascade of free radical oxidation stress develops in the brain tissues leading to an encephalitis situation similar to what happens with the cytokine storm and the production of respiratory distress