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When the early signal also happened to favor a lower dose over a higher one an inverted dose-response that is a classic warning sign of noise rather than a true pharmacological effect the case for genuine efficacy was already fragile before the pivotal trial delivered its verdict

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Daily methylcobalamin injections were administered at very high doses from 500 to 1000 g per kilo of bodyweight this would correspond to about 40 000 80 000 g per day for a human being

Once the peptides are reconstituted (mixed with bacteriostatic water) , they must be stored in the refrigerator to maintain their stability

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