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Preclinical studies in rodent models demonstrated increased fat oxidation and reduced adiposity without measurable changes in IGF-1 or blood glucose (Ng and Bornstein, 2000

[DOI] [PMC free article] [PubMed] [Google Scholar] 312.Elbarbry F., Ung A., Abdelkawy K

fermentum A51 may be due to its ability to produce superoxide dismutase (SOD), reduced glutathione (GSH), ferulic acid esterase (FAE), ferulic acid (FA), NADH oxidase and NADH peroxidase (Cheng et al., 2020)

Abbreviations CD: cluster of differentiation CTLA4: cytotoxic T lymphocyte antigen 4 DMARDs: disease-modifying anti-rheumatic drugs FLS: fibroblast-like synoviocytes FR: folate receptor GC: glucocorticoids GPI: glycosylphosphatidylinositol GM-CSF: granulocyte macrophage-colony-stimulating factor HLA-DRB1: human leucocyte antigen DRB1 iNOS: inducible nitric oxide synthase IL: interleukin M1-type macrophage: pro-inflammatory macrophages M2-type macrophages: anti-inflammatory macrophages MLS: macrophage-like synoviocytes M-CSF: macrophage-colony-stimulating factor MTX: methotrexate MRI: magnetic resonance imaging NSAIDs: nonsteroidal anti-inflammatory drugs PADI4: peptidyl arginine deaminase type 4 PET: positron emission tomography PTPN22: protein tyrosine phosphatase, non-receptor type 22 RA: rheumatoid arthritis SE: shared epitope STAT4: signal transducer and activator of transcription 4 TGF: transforming growth factor TLR: toll-like receptor TNF: tumor necrosis factor TNFAIP3: TNF alpha-induced protein 3 References Cross M, Smith E, Hoy D, Carmona L, Wolfe F, Vos T, et al

[0264] The term "naturally-occurring" as used herein as applied to an object refers to the fact that an object can be found in nature

Glutathione (GSH) is a simple yet profoundly powerful tripeptide composed of three amino acids: glutamate, cysteine, and glycine
