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PG is one of the commonly occurring species of Pulicaria in Iran, locally known as Alaf-e Heiyze or Kak kosh. It is a perennial or subshrub that primarily grows in temperate biomes and is native to Iraq, Central Asia, the Western Himalayas, and the Arabian Peninsula [104]

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In addition to NAD + , CD38 also catabolizes nicotinamide mononucleotide (NMN) and other extracellular NAD + precursors prior to their intracellular transport for NAD + biosynthesis (Fig