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Recent studies of the heart, lungs, and small blood vessels of the kidneys have shown that the EG is involved in some manifestations of endothelial dysfunction in sepsis (53, 55), and Song et al

MiRNAs Regulating the GH/IGF1 Axis and IGF System in Pituitary Adenomas Several studies concerning the involvement of miRNAs in regulating the GH/IGF1 axis and the IGF system have been conducted in GH-secreting pituitary adenomas, which are characterized by GH hypersecretion and lead to gigantism in children and acromegaly in adults (48)

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Key mechanisms include DNA methylation, histone modifications, and non-coding RNA-mediated regulations (Fig