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Apart from the remethylation to Met, Hcy also drives the synthesis of cystathionine via cystathionine -synthase (CBS)

This effect exacerbates overlap of J-coupled resonances with stronger signals, making it difficult to quantify the individual peaks of GSH with conventional MRS approaches, especially at lower field strengths (Harris et al., 2017)

doi: 10.1002/mco2.v4.4 344 FriuliMSepeCPanzaETravelliCPaternitiIRomanoA

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Subsequent examination indicated that (MeHg) 2 S is formed by the interaction of MeHg with reactive sulfur species (RSS), which exhibit high nucleophilicity 17,18 and include compounds such as GSH persulfide (GSSH) and protein-bound persulfide derived from CysSH persulfide (CysSSH) and hydrogen sulfide (H 2 S) produced by transsulfuration or enzymatic activities, such as cystathionine -lyase (CSE) activity 19 (see Fig