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Studies of Chinese Han population indicated that the T allele shown associated with schizophrenia as a risk allele 52 while a casecontrol association between the MTHFR C677T polymorphism and schizophrenia in a Japanese subjects research also demonstrated a strong linkage between the MTHFR C677T polymorphism and schizophrenia 53

At the peripheral level, in middle-aged individuals, and given the importance of circadian rhythms in lipid regulation and in their changing profile associated with metabolic problems (Dallmann et al., 2012