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For a 150lb person (about 68kg), a moderate dose of 20mg/kg would be roughly 1,360mg per day

Precautions Individuals with pre-existing kidney disease should avoid high dose glutathione

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Slow metabolizers accumulating peptides could achieve effects at lower doses

The widespread G-protein bias with minimal -arrestin-2 recruitment offers a plausible mechanistic explanation for kratoms atypical safety profile relative to classical opioids (Hemby et al., 2018

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